Our mission is to treat osteoarthritis and get people moving without pain.

about

Sparta is creating the first-of-its-kind chemically engineered cartilage platform, Galene.

The degeneration of cartilage between the joints can cause significant personal, economic, societal burden for individuals, families, and communities. In addition, acute injuries to joint cartilage can exacerbate and become debilitating over time.

We are developing cartilage-like implants for the knee and all of the important joints in the body.

solving a massive problem that affects the world’s population
address cartilage degeneration
intersection of chemistry, mechanical engineering, biology

Galene is a Multi-Indication Platform

Shoulder
Thumb
Partial knee
Ormi™
Patella
Elbow
Hip
Trochlea
Ankle
Toe

Leadership team

We are a team of operators, technologists, scientists, and engineers with long histories in the pharma, medtech, and nuclear arenas.

Dushyanth Surakanti
Dushyanth Surakanti
CEO & Co-Founder
Dimitrios Angelis
Dimitrios Angelis
President & Co-Founder
Benjamin Wiley, PhD
Benjamin Wiley, PhD
CTO & Lead Inventor
Demetrius Siachames, PE
Demetrius Siachames, PE
Director of Engineering
Travis Entrop
Travis Entrop
Senior R&D Engineer
Board of directors
Ken Gall, PhD
Independent Director
Independent Director
Neil S. Roth, MD
Independent Director
Independent Director
Sean Fontenot
Independent Director
Independent Director
Dimitrios Angelis
President & Co-Founder
Executive Director
Executive Director
Dushyanth Surakanti
CEO & Co-Founder
Executive Director
Executive Director
Scientific Advisory Board
Adam Yanke, MD, PhD
Kristofer J. Jones, MD
Jon Dickens, MD, LTC
Brian Waterman, MD
Seth Sherman, MD
Strategic Advisory Board
Artem Iaryguine
Artem Iaryguine
Strategic Advisor
Nick Pachuda, DPM
Nick Pachuda, DPM
Strategic Advisor
Kristen Moffat, PhD
Kristen Moffat, PhD
Strategic Advisor

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Clinical need

651M
People with knee osteoarthritis worldwide
16M
Annual visits as a result of knee pain
1.2M
Knee Cartilage repair procedures by 2030

We all have friends and family who are suffering from knee pain and limited range of motion. This is not only a problem locally, but globally. Over 500M suffer from osteoarthritis (OA). There are 16M visits in the US specifically for knee symptoms. In addition, there are hundreds of thousands osteochondral repairs per year. Unfortunately, there is a high percentage of patients who have a revision within two years. In addition, there are several million people getting a total knee replacement each year. A third of them were considered inappropriate candidates for this intervention. This issue also afflicts active military. Limited duty days exceed 1M after chondral procedures. One in three veterans have OA. The overall prevalence of knee cartilage lesions in high performance athletes is almost 40%.

our approach

We understand that behaviors and the environment can affect how one’s genes work. Furthermore, chronological age refers to the actual amount of time a person has existed, while biological age refers to epigenetic alteration and DNA methylation which express on how able and functioning a person is. The biological age of a joint is no different. Its condition is a result of prior injury, person’s daily routine, profession and diet.

Our proprietary Galene platform was developed with this reality in mind. This platform renders biological age inconsequential. Unlike cartilage regeneration technologies which take many months, if not years, to regrow strong cartilage, Galene mimics the properties of hyaline cartilage at time zero. This platform was developed at the intersection of materials science, chemistry, and engineering. Through a novel process of combining unique materials and well-known polymers, we created a bionic cartilage which replicates the tensile, compression, and wear properties in the joints of the shoulder, great toe, thumb, elbow, spine, and talus.  We modified the geometry and configuration based on the anatomical location of interest.  This allows us to more precisely and effectively address the needs of patients afflicted with osteoarthritis and cartilage defects. Our approach has the potential to provide patients with immediate pain reduction, full range of motion, resulting in a quality of life they desire.

The OrmiTM implant, a Breakthrough Device, was created by combining Galene with an osseointegrative titanium base.  OrmiTM is intended to treat chondral and osteochondral lesions of the femoral condyle.

immediate pain reduction
+
full range of motion
=
enhanced quality of life

Clinical Benefit

A Target Product Profile (TPP) is a set of outcomes that focuses our efforts on building a solution that meaningfully improves that standard of care. Along with satisfying many safety requirements, we set a high bar on those outcomes that matter most for patients. Our TPP is unmatched by existing treatments and technologies in development. We believe this will instill confidence in surgeons as they help their patients quickly resume their daily routines and while knowing many productive years lay ahead.

Surgeons can take comfort in knowing their patients will quickly resume their routines and have highly productive lives many years to come.

Biologic / Cartilage Regeneration*
OrmiTM
Dependent on patient’s biology
Yes
No
Full weight bearing
Pain reduction
Several weeks
1-2 days
Achieve full range of motion
Several days/weeks
Few days
Return to biking, jogging, sports
in 6-24 months
Within few weeks
Durability
5 years
At least 10yrs

Pipeline

We are building a substantial pipeline of OrmiTM solutions. We will leverage all the know-how and preclinical testing from our knee indication and create efficient and cost effective development paths for these additional indications.

Indication
Prototype
Pre-Clinical
Clinical
Femoral condyle
Unicondylar
Patella
Trochlea
OCD
CMC
MTP
Shoulder
Hip
Elbow
Talus

IN the news

Jan 31, 2023
Oct 10, 2022
Sep 13, 2022
Aug 18, 2022

Resources

Computational and Image Processing Methods for Analysis and Automation of Anatomical Alignment and Joint Spacing in Reconstructive Surgery
Computational and Image Processing Methods for Analysis and Automation of Anatomical Alignment and Joint Spacing in Reconstructive Surgery
Authors: Usamah N. Chaudhary, Cambre N. Kelly, Benjamin R. Wesorick, Cameron M. Reese, Ken Gall, Samuel B. Adams, Guillermo Sapiro, J. Matias Di Martino
Reference: International Journal of Computer Assisted Radiology and Surgery (2022).
 Dimitrios Angelis Presents Sparta Biomedical at LSI USA '23
Dimitrios Angelis Presents Sparta Biomedical at LSI USA '23
A Synthetic Hydrogel Composite with a Strength and Wear Resistance Greater than Cartilage
A Synthetic Hydrogel Composite with a Strength and Wear Resistance Greater than Cartilage
Authors: Jiacheng Zhao, Huayu Tong, Alina Kirillova, William J. Koshut, Andrew Malek, Natasha C. Brigham, Matthew L. Becker, Ken Gall, and Benjamin J. Wiley
Reference: Wiley Online Library (2022)
A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage
A Synthetic Hydrogel Composite with the Mechanical Behavior and Durability of Cartilage
Authors: Feichen Yang, Jiacheng Zhao, William J. Koshut, John Watt, Jonathan C. Riboh, Ken Gall, Benjamin J. Wiley
Reference: Wiley Online Library (2020)
Functional repair of critically sized femoral defects treated with bioinspired titanium gyroid-sheet scaffolds
Functional repair of critically sized femoral defects treated with bioinspired titanium gyroid-sheet scaffolds
Authors: Cambre N. Kelly, Angela SP. Lin, Kelly EH. Leguineche, Sudhanshu Shekhar, William R. Walsh, Robert E. Guldberg, Ken Gall
Reference: Journal of the Mechanical Behavior of Biomedical Materials (2021).
High-Strength Hydrogel Attachment through Nanofibrous Reinforcement
High-Strength Hydrogel Attachment through Nanofibrous Reinforcement
Authors: Jiacheng Zhao, Alina Kirillova, Cambre N. Kelly, Heng Xu, William J. Koshut, Feichen Yang, Ken Gall, Benjamin J. Wiley
Reference: Wiley Online Library (2020).
High-strength, porous additively manufactured implants with optimized mechanical osseointegration
High-strength, porous additively manufactured implants with optimized mechanical osseointegration
Authors: Cambre N.Kelly, TianWang, JamesCrowley, DanWills, Matthew H. Pelletier, Edward R.Westrick, Samuel B.Adams, KenGall, William R.Walsh
Reference: Biomaterials (2021).
Sparta Biomedical in WXII 12 News: Clinical trials expected to begin sometime this year.
Sparta Biomedical in WXII 12 News: Clinical trials expected to begin sometime this year.
Sparta Biomedical video at the World Economic Forum
Sparta Biomedical video at the World Economic Forum
Stiff, Achy Knees? Lab-Made Cartilage Gel Outperforms the Real Thing
Stiff, Achy Knees? Lab-Made Cartilage Gel Outperforms the Real Thing
Author: Robin A. Smith
Reference: Duke University

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